ADCs and bioconjugates

Our scientists have extensive experience in providing services related to the synthesis and characterisation of antibody-drug conjugates (ADCs) and other bioconjugates. We have worked with a variety of highly potent payloads, as well as a selection of cleavable and non-cleavable linkers and spacers. We can also provide a number of different linker strategies in order to fine tune activity and stability in various media.

Our synthetic services related to ADC and bioconjugates include:
  • Preparation and purification of ADCs and other bioconjugates
  • Design and synthesis of payloads, spacers and linkers 
  • Modification of carbohydrates, including polysaccharides and glycoconjugates
  • Preparation and purification of lipids and conjugates thereof
  • Preparation and purification of fluorescent probes
Our analytical support methods include:
  • High performance liquid chromatography (HPLC)
    • Reversed-phase chromatography (RP)
    • Size-exclusion chromatography (SEC)
    • Hydrophobic interaction chromatography (HIC)
  • Triple quadrupol mass spectrometry (MS TQ)
  • Mass spectrometry quadrupole time-of-flight (MS QTOF)
  • Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (Maldi-TOF MS)
  • Nuclear magnetic resonance (NMR)
  • Ultraviolet-visible light spectrophotometry (UV/Vis)

Additional characterisation and analyses are also available.

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