Poorly soluble drugs

Many new drug substances have a poor solubility and/or slow dissolution rate. This often causes problems like poor and variable bioavailability as well as slow onset of action. Fortunately, there are a number of options available for a skilled formulator to address these problems.

In order to increase solubility we work with salt selection, pH-adjustments, co-solvents, surfactants and complexation with cyclodextrins. We can also prepare amorphous drug substance by spray drying. The dissolution rate can be increased by micronisation or wet milling to nanosize particles. 

Optimised excipient selection

We recognise that low aqueous solubility of drug molecules is a major challenge in the development of liquid formulations, driving the need for new and efficient methods in selecting solubilising excipients. Recipharm’s formulation team has introduced our proprietary high-throughput screen (HTS) platform for solubility testing to help you achieve optimum formulation for your molecule faster than ever.

At every stage of the formulation process we are dedicated to ensuring that your development pathway is as efficient as possible. Our HTS approach overcomes the challenges of manual techniques by rapidly identifying the solubilisation capacity and stability of a compound in a range of excipients. The automated process performs multiple tests simultaneously to provide conclusive information about your compound’s solubility and stability, ensuring your target drug dosage forms are reached.

Amorphous formulation development

Amorphous formulation development is an emerging bioavailability enhancement technique. It is a cost effective means of turning promising yet hard to formulate drug candidates into effective drugs.

Recipharm’s solubility enhancement service helps developers use amorphous formulation development to increase the bioavailability of poorly soluble active pharmaceutical ingredients (API).

Our team employs a range of solubility enhancement techniques to help customers achieve formulations that have enhanced properties, with the ultimate aim being to help develop more effective medicines.

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