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Vaccine production is a very complex process, making specialist expertise vital to ensuring both the safety and efficacy of the final product. However, depending on the type of vaccine, different approaches are required.

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Inhalation products are extremely complex to develop and manufacture, and it is important to understand potential interactions between the formulation and the delivery device throughout the development stages.

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User-friendly drug design is about so much more than improving delivery devices. When it comes to reducing the administration burden for patients, modified-release formulations drugs can also help.

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All eyes have been on the pharmaceutical industry throughout 2020 and the start of 2021 - assessing its capacity to provide an answer to a truly global challenge. 

The pandemic has highlighted vulnerabilities in the industry’s highly globalized supply chain.

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Tackling the challenges of combination drug development can be difficult. There are many obstacles facing developers of combination inhalation treatments, so what are they and how can they be overcome?

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Arnaud C. Tiberghien, Philip W. Howard, William R. F. Goundry, Marc McCormick and Jeremy S. Parker. 
  Recipharms Elfyn Jones and Mikael Hillgren supported with the upscale of intermediate that made this article possible.

Insights

Oral solid dosage (OSD) products remain the largest segment of the pharmaceutical market. Oral solids continue to be the most commonly used delivery vehicle to get drugs to patients. There are three main factors for this: they are cost-effective, relatively easy to manufacture, and most importantly, are patient friendly.

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The COVID-19 pandemic has exposed several weaknesses in global pharmaceutical supply chains, this is particularly true when it comes to APIs. Governments have responded forcefully with production relocation initiatives encouraging manufacturers to source supplies from closer to home. 

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There are several novel approaches to improving bioavailability and solubility that have one commonality: they treat each molecule as unique. 

Recipharm’s approach is to use conventional technologies whenever possible, as this will usually be more time- and cost-effective.

Insights

The last five to ten years have seen substantial changes across the pharmaceutical industry, many of which have had a significant impact on the dosage forms used for the administration of drugs. 

All of these developments are translating into rapid evolution for the dosage forms we use to deliver drugs to patients.