The key stages for establishing spray characterisation for orally inhaled and nasal drug products

Inhalation products are some of the most complicated and challenging drug dosage forms and are extremely complex to develop and manufacture. It is important to understand potential interactions between the formulation and the delivery device throughout the development stages, as well as when it reaches the end user. 

For spray characterisation, real-time images of aerosols or sprays emitted from the device through a laser sheet are acquired using a high-speed camera.

Orally inhaled and nasal drug products (OINDPs) including nasal sprays, oral sprays, and metered-dose inhalers (MDIs), are particularly complex, due to the part played by spray performance in successful drug delivery. 

Spray performance covers a range of parameters, such as droplet size distribution, spray pattern (SP) and plume geometry (PG). These can all have a significant impact on effective administration of a drug dose unless steps are taken to control them and minimise variability. 

In an article with On Drug Delivery, our Francois Billard, Associate Director of Analytical Services Sales and Lei Mao, Director of Inhalation Science and Product Development look at measurement systems for spray pattern and plume geometry dispensed by orally inhaled and nasal drug products.

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