OSD

Antibody–drug conjugates (ADCs) are an emerging type of biotherapeutics for the treatment of cancer. By utilizing multiple tissue specific antibodies combined with a range of linker designs ADCs can enable the transportation and selective release of cytotoxic drugs in close proximity to tumours.

Antibody–drug conjugates (ADCs) are an emerging type of biotherapeutics that utilize multiple tissue specific antibodies combined with a range of linker designs to enable the transportation and selective release of cytotoxic drugs in close proximity to tumours.

In this paper, produced with the Royal Society of Chemistry, our authors present a unique experimental comparison of four techniques for ADC analysis: hydrophobic interaction chromatography (HIC-UV/Vis), reversed phase liquid chromatography mass spectrometry (RPLC-MS), using either a QToF or an Orbitrap analyser, and matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF-MS). The aim was to determine which of the techniques would be better for initial screenings in the early discovery phases of new ADCs.

You can read the full paper here