Job Summary

This position reports to the Head of Technical Operations and plays a key role in leading laboratory /experimental approaches for optimized RNA production. They will lead the efforts to design, execute, and interpret critical experiments for the success of various RNA modalities in activities including IVT high throughput screening, downstream development, process scale-up and tech transfer. This role will also support downstream process development for plasmid purification and related analytical development for in-process monitor and final product release. The individual will work collaboratively in a cross-functional environment including analytics, tech transfer, GMP manufacturing and Quality. The successful candidate has a big potential to grow as a leader in nucleic acid process science group.

 Essential Job Function

  • Serve as a scientific/laboratory leader to guide & mentor scientists and associates within RNA process science team
  • Serve as a Subject Matter Expert in RNA process to lead RNA process development activities in a combination of customer related, and internal related projects. These may include technology transfer, technology establishment, scale up manufacturing, process optimization, platform development.
  • Assist in plasmid downstream process development using related chromatography and filtration technologies.
  • Design & execute complex and technically challenging experiments for trouble shooting and method development.
  • Support leadership team to evaluate new technologies and lead internal/external technical collaborations.
  • Evaluate functional strengths and identify developmental areas with the ability to focus on continuous improvement
  • Represent plasmid process development in cross-functional team forums including GMP manufacturing/non-GMP manufacturing, interdepartmental meetings, etc.
  • Lead presentation, publication and/or patenting of findings or is a major contributor to these processes.

 Experience And Skills

  • Experts with extensive hands-on experience in production of mRNA, saRNA, siRNA, circRNA, and/or other RNA modalities.
  • Extensive hands-on experience in process characterization and common RNA analytics.
  • Deep knowledge in IVT reaction optimization and mRNA downstream unit operations.
  • Experience with statistical design of experiments (DOE) is a plus.
  • Experience with commercial scale up, large-scale bio-manufacture and cGMP is a plus.
  • Ability to independently design experiments, analyze complex data and interpret and present experimental results, required.

 PHYSICAL DEMANDS

The physical demands described here are representative of those that must be met by an employee to successfully perform the essential functions of this job. Reasonable accommodations may be made to enable individuals with disabilities to perform the essential functions.

  •  While performing the duties of this job, the employee is frequently required to stand; sit; use hands to finger, handle, or feel; reach with hands and arms; and talk or hear.
  • The employee is occasionally required to walk; climb or balance; and stoop, kneel, crouch, or crawl.
  • The employee must frequently lift and/or move up to 10 pounds and occasionally lift and/or move up to 25 pounds.
  • Specific vision abilities required by this job include close vision, and ability to adjust focus.
  • In the performance of the duties of this job the employee is not required to travel
  • The employee will be required to communicate using telephone and e-mail.

Annual Base Salary Range from $145,000 to $155,000

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