OSD
How do you improve the solubility of an extremely poorly soluble active substance while still achieving the controlled release needed for an extended-release product?
This case study shows how our formulation and analytical experts combined cyclodextrin complexation with a pharmacokinetically informed release strategy to address both requirements. The approach translated a complex formulation concept into a practical, manufacturable tablet, supported by a comprehensive data package.
See how a science-led approach helped balance solubility, release performance and manufacturability within a compressed development timeframe.
Key highlights
- Addressing poor solubility while achieving extended release
- Using pharmacokinetics to inform the target release profile
- Turning a complex formulation concept into a manufacturable tablet
- Delivering the full development scope within a compressed timeframe