OSD

Recipharm’s Torkel Gren joins Synthonics and Rush University representatives to discuss a new technology that improves pharmacokinetic (PK) properties in metal coordinated pharmaceuticals (MCPs).

Because the chemistry is relatively efficient and inexpensive to practise, compounds can often be developed and preliminary data attained in a matter of months.

A review of around 3000 listed drugs found that over 400 have structures that allow metal coordination. This inexpensive technique involves attaching acceptable metals such as zinc or magnesium to pharmaceutical agents in order to create new and more effective drugs. The process can change the way a drug is absorbed or delivered without altering the actions of the drug itself.

In an article published by Chemistry Today, Torkel Gren discusses this potentially powerful and flexible tool for drug development and its use to improve the PK parameters of two well-known drugs.

Download and read the article in full here:

Metal coordinated pharmaceuticals: A new technology for improved PK properties