OSD
Rafael Hartmanna, Jonas Malmströma, Graham Sibleyb and Fredrik Lehmann
Syn lett, R. Hartmann et al. 20.01.2016
Abstract: 6H-1,3,4-Thiadiazines are a promising class of non-aromatic heterocycles for the agricultural and pharmaceutical industry. Although known for a long time, they have not received widespread attention, in part due to their cumbersome synthesis. The novel route described herein for the direct transformation of aromatic alkyl ketones into 5- aryl-6H-1,3,4-thiadiazine-2-amines provides moderate to excellent yields while employing readily available reagents under mild reaction conditions.
Keywords
cyclization, heterocycles, carbazones, chemoselectivity, one-pot procedure