OSD

Dr Amjad Alhalaweh, a formulation scientist at Recipharm, takes to Pharmaceutical Manufacturing to discuss a new high-throughput screening (HTS) method for identifying suitable excipients to solubilise compounds during drug development.

The approach involved testing the interactions of 30 different excipients with six commercially available drugs, with a diverse range of properties.

During the drug development phase, the pharmacology, pharmacokinetic and toxicology properties of a compound need to be evaluated. This requires a liquid formulation. However, sometimes a drug candidate can be poorly soluble meaning excipients are required to improve its dissolution properties to allow scientists to complete this part of the development process.

The current methodologies used to select excipients are manual processes and rely on a trial-and-error based approach, which is very time-consuming and requires a substantial amount of raw material. To save time and money, drug developers are looking to find an alternative screening process for selecting appropriate excipients. Scientists at Recipharm have developed a new HTS method, which can help to automate the excipient selection process and provide conclusive results on the chemical stability of compounds.

In this article, Dr. Amjad Alhalaweh explores the experimental findings of the HTS method. Read the piece here:

Automating excipient selection