OSD
In early drug development, the toxicology, bioavailability, pharmacokinetics (PK) and pharmacology of a compound need to be analysed using a liquid formulation. Often solubility becomes a challenge, meaning excipients are needed to optimise the solubility. Yet, currently, the selection of excipients is reliant on a trial and error approach that is both time-consuming and costly, creating a demand for an alternative methodology. In an article published in Pharmaceutical Technology, Dr Amjad Alhalaweh, a Research Scientist at Recipharm discusses the development of a novel high throughput screening method.
The method can provide information on the solubilisation capacity of compounds in different excipients, while also offering insight into stability.
More cost-effective and economical in its use of materials, this new method has been found to overcome the challenges present in the manual approach. It also enables a turnaround of just 3 to 5 days per sets of compounds.
This advancement not only creates new possibilities in terms of drug development timelines and costs, but can offer information that is useful in the later stages, helping to increase the chances of successful formulations.
Read the full article here: